Living donation provides important access to organ transplantation, which is the optimal therapy for patients with end-stage liver or kidney failure. Paired exchanges have facilitated thousands of kidney transplants and enable transplantation when the donor and recipient are incompatible. However, frequently willing and otherwise healthy donors have contraindications to the donation of the organ that their recipient needs. Trans-organ paired exchanges would enable a donor associated with a kidney recipient to donate a lobe of liver and a donor associated with (...) a liver recipient to donate a kidney. This article explores some of the ethical concerns that trans-organ exchange might encounter including unbalanced donor risks, the validity of informed consent, and effects on deceased organ donation. (shrink)

Nothing seems to follow strictly from 'X believes that p'. But if we reinterpret it to mean: 'X can consistently be described as consistently believing p'--which roughly renders, I think, Hintikka's notion of "defensibility"--we can get on with the subject, freed from the inhibitions of descriptive adequacy. But defensibility is neither necessary nor sufficient for truth: it tells us little, therefore, about the concept of belief on which it is based. It cannot, in particular, specify necessary conditions for the consistent (...) ascription of belief--as opposed to rational belief. If there are no such conditions, all belief ascriptions must be treated as atomic: which is implausible. If there are some, they must be settled on before an account of consistency can be complete. The reason is simple: it is that we have beliefs about our own beliefs. A set of first order beliefs is consistent if they can all be true together; but it is a lesson of Moore's paradox that consistency of second-order beliefs requires additional constraints. If someone both believes that p and that he does not believe that p, the propositions he believes might all be true together, yet he is inconsistent. And the characterization of second order consistency will remain incomplete, so long as nothing is said about the consistency of first order belief ascriptions. Suppose someone says and believes: "I am inconsistent: I believe both p and ~p." This is "indefensible": but is it insight, or nonsense? Breast-beating of this sort is guaranteed success: something he believes is bound to be false. But that remains diagnostically frustrating: is he inconsistent because what he said is true, or on the contrary because it is inconsistent? (shrink)

Welch :263–279, 2017) has recently proposed two possible explanations for why the field of evolutionary biology is plagued by a steady stream of claims that it needs urgent reform. It is either seriously deficient and incapable of incorporating ideas that are new, relevant and plausible or it is not seriously deficient at all but is prone to attracting discontent and to the championing of ideas that are not very relevant, plausible and/or not really new. He argues for the second explanation. (...) This paper presents a twofold critique of his analysis: firstly, the main calls for reform do not concern the field of evolutionary biology in general but rather, or more specifically, the modern evolutionary synthesis. Secondly, and most importantly, these calls are not only inspired by the factors, enumerated by Welch, but are also, and even primarily, motivated by four problematic characteristics of the modern synthesis. This point is illustrated through a short analysis of the latest reform challenge to the modern synthesis, the so-called extended evolutionary synthesis. We conclude with the suggestion that the modern synthesis should be amended, rather than replaced. (shrink)

Introduction. Bert HAMMINGA and Neil DE MARCHI: Préface. Bert HAMMINGA and Neil DE MARCHI: Idealization and the Defence of Economics: Notes Toward a History. Part I: General Observations on Idealization in Economics. Kevin D. HOOVER: Six Queries about Idealization in an Empirical Context. Bernard WALLISER: Three Generalization Processes for Economic Models. Steven COOK and David HENDRY: The Theory of Reduction in Econometrics. Maarten C.W. JANSSEN: Economic Models and Their Applications. Adolfo GARCÍA DE LA SIENRA: Idealization and Empirical Adequacy in Economic (...) Theory. Izabella NOWAKOWA and Leszek NOWAK: On Correspondence between Economic Theories. Uskali MÄKI: Isolation, Idealization and Truth in Economics. Part II: Case Studies of Idealization in Economics. Nancy CARTWRIGHT: Mill and Menger: Ideal Elements and Stable Tendencies. Wolfgang BALZER: Exchange Versus Influence: A Case of Idealization. Kees COOLS, Bert HAMMINGA, Theo A.F. KUIPERS: Truth Approximation by Concretization in Capital Structure Theory. Daniel M. HAUSMAN: Paul Samuelson as Dr. Frankenstein: When an Idealization Runs Amuck. Hugo A. KEUZENKAMP: What if an Idealization is Problematic? The Case of the Homogeneity Condition in Consumer Demand. Werner DIEDERICH: Nowak on Explanation and Idealization in Marx's 'Capital'. Gérard JORLAND: Idealization and Transformation. Jack BIRNER: Idealizations and Theory Development in Economics. Some History and Logic of the Logic Discovery. Discussions. Leszek NOWAK: The Idealizational Methodology and Economics. Replies to Diederich, Hoover, Janssen, Jorland and Mäki. (shrink)

Modelos neurocognitivos têm sido propostos para investigar a consciência. O objetivo é responder à pergunta sobre como o cérebro é capaz de produzir estados conscientes qualitativos. Os modelos são representações teóricas baseadas em algumas pesquisas empíricas. Contudo, a questão central, aparentemente trivial para alguns autores, refere-se à representatividade e confiabilidade dos modelos, i.e., saber se são capazes de explicar como a consciência emerge de processos neurais. Esses modelos são considerados como guia no estudo científico da consciência: os modelos cognitivos de (...) Dennett e Baars, os modelos neurobiológicos de Edelman, Dehaene et al., de Damásio, e o modelo neurodinâmico proposto por Freeman. O presente texto visa a analisar a coerência e a plausibilidade dos modelos, i.e., se realmente explicam a “consciência” e suas propriedades em termos neurais ou se explicam apenas mecanismos neurobiológicos subjacentes no cérebro. O objetivo é avaliar escopo e limites dos modelos além da aplicabilidade na resolução do problema da consciência. Neurocognitive models are proposed in order to study the problem of consciousness. The models are attempts to answer the question of how the brain can generate conscious and qualitative states. Models are theoretical representations based on empirical data. Nonetheless, the central question concerns the reliability and the representativeness of the models, i.e., whether they in fact represent what they are supposed to explain, viz., how consciousness can emerge from neuronal processes. Such models are taken to be a guide for the scientific study of consciousness. Presently, there are six models: the multiple draft, the global workspace, the dynamic core, the global neuronal workspace, the somatic markers hypothesis, and the neurodynamic model. This text is a survey and a philosophical analysis of the models of consciousness, and it considers their plausibility and coherence. I will concentrate on two points: whether the neuroscientific models are able to explain ‘consciousness’ and its properties in neural terms, or whether the models only explain the neural correlates of conscious states, and the scope, limitations and applicability of the models in the attempt to solve the problem of consciousness. (shrink)

Marcel Beaufils fut un pedagogue exceptionnel qui exerca une influence decisive sur l'evolution de l'esthetique musicale en France, a partir des annees 50. Or, parmi ses ouvrages, Musique du son, musique du verbe est tres certainement celui qui porte le plus fortement la marque de son activite d'enseignant au Conservatoire National Superieur de Musique de Paris ; cette mission, il semblait l'entendre davantage comme celle d'un declencheur d'idees, catalyseur, plutot que du transmetteur d'un savoir fige une fois pour toutes. Bouleversant (...) toute tentative de classification academique, toute certitude acquise, ce livre laisse des pointilles ; un grand souffle traverse son ecriture. N'en deplaise aux musicographes, il s'agit la d'un ouvrage de creation, qui nous rappelle que Marce Beaufils etait egalement un ecrivain qui savait manier le verbe a la fois en tant que dramaturge et en tant que poete. (shrink)

Este texto procura traçar algumas linhas gerais da articulação entre música e ironia (ou audição musical e hermenêutica) no romantismo. Procura-se explorar a apropriação original que Søren Kierkegaard fez das “técnicas” hermenêuticas desenvolvidas por Friedrich Schlegel e Friedrich Schleiermacher.

Conheci Raduan num sábado entre junho ou julho de 1996. Estimo os meses e garanto o dia e o ano em razão de Menina a caminho. Amizades comuns nos levaram então a participar de festa familiar no paulistano bairro do Pacaembu. Situado em rua tranquila, o restaurado sobrado compunha-se das variadas dependências requeridas em outros tempos por famílias de classes em fase de ascensão. No piso térreo, destacava-se o espaço destinado aos convidados: a ampla sala, integrada à copa e a (...) um ajardinado terraço. Sobretudo ali as crianças da casa e de vários convidados comiam, corriam e algazarreavam. (shrink)

RESUMO A partir do exame da tradição heraclitiana e platônica sobre a transitoriedade e a imortalidade - conceitos compreendidos como universais - este artigo defende a seguinte antinomia como tese: para haver temporalidade é preciso haver eternidade. Essa tese é demonstrada por meio do estudo e atualização das noções de alma, espírito, ideia e memória, as quais estão conectadas invariavelmente ao tempo passado como princípio ontológico do fenômeno histórico. Para além do ponto de vista filosófico, portanto, da perspectiva específica do (...) conhecimento histórico, este estudo expõe algumas implicações teóricas acerca das condições de possibilidade da história, que são discutidas, finalmente, em diálogo com Friedrich Nietzsche e Jacob Burckhardt. ABSTRACT From the analysis of the Heraclitian and Platonic tradition on transience and immortality - understood as universal concepts - this essay defends the following antinomy as its thesis: if there is temporality there must be eternity. This thesis is demonstrated through the study and updating of the notions of soul, spirit, idea and memory, which are invariably connected to the past as the ontological principle of the historical phenomenon. Beyond the philosophical point of view, therefore, from the specific perspective of historical knowledge, this study exposes some theoretical implications about the conditions of possibility of history, which are finally discussed in dialogue with Friedrich Nietzsche and Jacob Burckhardt. (shrink)

This paper concentrates on the possible segregation of indium and gallium and competitive segregation of gallium and indium at atomically flat parallel {111}-oriented Cu-MnO interfaces. The segregation of gallium at Cu-MnO interfaces after introduction of gallium in the copper matrix of internally oxidized Cu-1 at.% Mn could be hardly detected with energy-dispersive spectrometry in a field emission gun transmission electron microscope. After a heat treatment to dissolve indium in the copper matrix, gallium has a weak tendency to segregate, that is (...) 2.5 at.% Ga per monolayer at the interface compared with 2 at.% in the copper matrix. The striking result is that this gallium segregation is observable because it does not occur at the metal side of the interface but in the first two monolayers at the oxide side. Using the same heat treatment as for introducing indium in the sample, but without indium present, gallium segregates strongly at the oxide side of the Cu-MnO interface with a concentration of about 14.3 at.% in each monolayer of the two. In contrast, the presence of gallium has no influence on the segregation of indium towards Cu-MnO interfaces, because the outermost monolayer at the metal side of the interface contains 17.6 at.% In, that is similar to previously found results. This leads to the intriguing conclusions, firstly, that, in contrast with antimony and indium, gallium segregates at the oxide side of the interface and, secondly, that the presence of indium strongly hampers gallium segregation. The results from analytical transmission electron microscopy on gallium segregation are supported by high-resolution transmission electron microscopy observations. (shrink)

RESUMO Este artigo objetiva ser uma breve introdução à práxis soteriológica budista, enfatizando, num primeiro momento, as quatro nobres verdades, aquele conjunto de intuições fundamentais formuladas pelo Buda desde o seu primeiro sermão; depois se descreve o nobre óctuplo caminho, o conjunto de práticas ensinadas pelo Buda para a consecução da experiência do despertar; finalmente, descrevem-se os estágios do caminho tanto no ambiente theravādin quanto na tradição mahāyāna. ABSTRACT This article aims at being a brief introduction to the soteriological praxis (...) of Buddhism, underscoring, firstly, the four noble truths, that set of cornerstone intuitions propounded by the Buddha since his first sermon; then, the noble eightfold path, the set of practices that aims at the experience of awakening taught by the Buddha is described; finally, the stages of the way are described, both in the theravādin tradition as well as in mahāyāna's. (shrink)